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Drosophila Homologue of the Rothmund-Thomson Syndrome Gene: Essential Function in DNA Replication During Development

Members of the RecQ family play critical roles in maintaining genome integrity. Mutations in human RecQL4 cause a rare genetic disorder, Rothmund-Thomson syndrome. Transgenic mice experiments showed that the RecQ4 null mutant causes embryonic lethality. Although biochemical evidence suggests that th...

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Detalhes bibliográficos
Main Authors: Wu, Jianhong, Capp, Christopher, Feng, Liping, Hsieh, Tao-shih
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600506/
https://ncbi.nlm.nih.gov/pubmed/18755177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2008.08.006
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