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Structural determinants of Kvβ1.3-induced channel inactivation: a hairpin modulated by PIP(2)
Inactivation of voltage-gated Kv1 channels can be altered by Kvβ subunits, which block the ion-conducting pore to induce a rapid (‘N-type') inactivation. Here, we investigate the mechanisms and structural basis of Kvβ1.3 interaction with the pore domain of Kv1.5 channels. Inactivation induced b...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Publishing Group
2008
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2599874/ https://ncbi.nlm.nih.gov/pubmed/18987637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.231 |
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