Structural determinants of Kvβ1.3-induced channel inactivation: a hairpin modulated by PIP(2)

Inactivation of voltage-gated Kv1 channels can be altered by Kvβ subunits, which block the ion-conducting pore to induce a rapid (‘N-type') inactivation. Here, we investigate the mechanisms and structural basis of Kvβ1.3 interaction with the pore domain of Kv1.5 channels. Inactivation induced b...

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Main Authors: Decher, Niels, Gonzalez, Teresa, Streit, Anne Kathrin, Sachse, Frank B, Renigunta, Vijay, Soom, Malle, Heinemann, Stefan H, Daut, Jürgen, Sanguinetti, Michael C
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2599874/
https://ncbi.nlm.nih.gov/pubmed/18987637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.231
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