In vivo formation of hybrid toxins comprising Shiga toxin and the Shiga-like toxins and role of the B subunit in localization and cytotoxic activity.

Shiga toxin, Shiga-like toxin I (SLT-I) and Shiga-like toxin II (SLT-II) are cell-associated cytotoxins that kill both Vero cells and HeLa cells, whereas Shiga-like toxin II variant (SLT-IIv) is an extracellular cytotoxin that is more cytotoxic for Vero cells than for HeLa cells. The basis for these...

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Udgivet i:Infect Immun
Main Authors: Weinstein, D L, Jackson, M P, Perera, L P, Holmes, R K, O'Brien, A D
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC259899/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2807546/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.57.12.3743-3750.1989
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