In vivo formation of hybrid toxins comprising Shiga toxin and the Shiga-like toxins and role of the B subunit in localization and cytotoxic activity.

Shiga toxin, Shiga-like toxin I (SLT-I) and Shiga-like toxin II (SLT-II) are cell-associated cytotoxins that kill both Vero cells and HeLa cells, whereas Shiga-like toxin II variant (SLT-IIv) is an extracellular cytotoxin that is more cytotoxic for Vero cells than for HeLa cells. The basis for these...

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Pubblicato in:	Infect Immun
Autori principali:	Weinstein, D L, Jackson, M P, Perera, L P, Holmes, R K, O'Brien, A D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1989
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC259899/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2807546/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.57.12.3743-3750.1989
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