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Acrolein, a Toxicant in Cigarette Smoke, Causes Oxidative Damage and Mitochondrial Dysfunction in RPE Cells: Protection by (R)-α-Lipoic Acid

PURPOSE: To understand better the cell and molecular basis for the epidemiologic association between cigarette smoke, oxidant injury, and age-associated macular degeneration, the authors examined the effects of acrolein, a major toxicant in cigarette smoke, on oxidative mitochondrial damage in retin...

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Detalhes bibliográficos
Main Authors: Jia, Lihong, Liu, Zhongbo, Sun, Lijuan, Miller, Sheldon S., Ames, Bruce N., Cotman, Carl W., Liu, Jiankang
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597695/
https://ncbi.nlm.nih.gov/pubmed/17197552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.06-0248
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