Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen

Patients and rodents with Goodpasture’s syndrome (GPS) develop severe autoimmune crescentic glomerulonephritis, kidney failure, and lung hemorrhage due to binding of pathogenic autoantibodies to the NC1 domain of the alpha3 chain of type IV collagen. Target epitopes are cryptic, normally hidden from...

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Auteurs principaux: Zhang, Ying, Su, Susan C., Hecox, Douglas B., Brady, Graham F., Mackin, Katherine M., Clark, Amy G., Foster, Mary H.
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597645/
https://ncbi.nlm.nih.gov/pubmed/18941198
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