Cross-talk of GATA-1 and P-TEFb in megakaryocyte differentiation

The transcription factor GATA-1 participates in programming the differentiation of multiple hematopoietic lineages. In megakaryopoiesis, loss of GATA-1 function produces complex developmental abnormalities and underlies the pathogenesis of megakaryocytic leukemia in Down syndrome. Its distinct funct...

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Autori principali: Elagib, Kamaleldin E., Mihaylov, Ivailo S., Delehanty, Lorrie L., Bullock, Grant C., Ouma, Kevin D., Caronia, Jill F., Gonias, Sara L., Goldfarb, Adam N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2008
Soggetti:
Hematopoiesis and Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597596/
https://ncbi.nlm.nih.gov/pubmed/18780834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-145722
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