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The synthesis of a geminally perfluoro-tert-butylated β-amino acid and its protected forms as potential pharmacokinetic modulator and reporter for peptide-based pharmaceuticals
[Figure: see text] To modulate and report the pharmacokinetics of peptide-based pharmaceuticals, a novel geminally perfluro-tert-butylated β-amino acid (βFa) and its Fmoc- and Boc- protected forms were designed and synthesized. βFa was incorporated into a model tripeptide via standard solid-phase ch...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597546/ https://ncbi.nlm.nih.gov/pubmed/17243713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo0616308 |
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