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Synthesis of Perfluoro-tert-butyl Tyrosine, for Application in (19)F NMR, via a Diazonium Coupling Reaction

A practical synthesis of the novel highly fluorinated amino acid Fmoc-perfluoro-tert-butyl tyrosine was developed. The sequence proceeds in 2 steps from commercially available Fmoc-4-NH(2)-phenylalanine, via diazotization followed by diazonium coupling reaction with perfluoro-tert-butanol. In peptid...

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Bibliografske podrobnosti
izdano v:Org Lett
Main Authors: Tressler, Caitlin M., Zondlo, Neal J.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6354588/
https://ncbi.nlm.nih.gov/pubmed/27978684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.6b02858
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