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Novel N7- and N1- substituted cGMP derivatives are potent activators of cyclic nucleotide-gated channels

Cyclic nucleotide-gated (CNG) channels, key players in olfactory and visual signal transduction, generate electrical responses to odorant- and light-induced changes in cyclic nucleotide concentration. Previous work suggests that substitutions are tolerated solely at the C8 position on the purine rin...

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Detalhes bibliográficos
Main Authors: Strassmaier, Timothy, Karpen, Jeffrey W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597524/
https://ncbi.nlm.nih.gov/pubmed/17665892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0702581
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