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Novel N7- and N1- substituted cGMP derivatives are potent activators of cyclic nucleotide-gated channels
Cyclic nucleotide-gated (CNG) channels, key players in olfactory and visual signal transduction, generate electrical responses to odorant- and light-induced changes in cyclic nucleotide concentration. Previous work suggests that substitutions are tolerated solely at the C8 position on the purine rin...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597524/ https://ncbi.nlm.nih.gov/pubmed/17665892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0702581 |
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