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Evaluation of recombinant Onchocerca volvulus activation associated protein-1 (ASP-1) as a potent Th1-biased adjuvant with a panel of protein or peptide-based antigens and commercial inactivated vaccines

Alum, the only adjuvant approved for clinical applications, can induce strong humoral (Th2) but weak cellular (Th1) immune responses. It is necessary to develop safe and effective adjuvants capable of inducing both humoral and cellular immune responses. We previously showed that activation-associate...

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Dettagli Bibliografici
Autori principali: Xiao, Wenjun, Du, Lanying, Liang, Chao, Guan, Jie, Jiang, Shibo, Lustigman, Sara, He, Yuxian, Zhou, Yusen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597511/
https://ncbi.nlm.nih.gov/pubmed/18675867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2008.07.028
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