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Deducing the transmembrane domain organization of presenilin-1 in γ-secretase by cysteine disulfide crosslinking
γ-Secretase is a founding member of membrane-embedded aspartyl proteases that cleave substrates within transmembrane domains, and this enzyme is an important target for the development of therapeutics for Alzheimer’s disease. The structure of γ-secretase and its precise catalytic mechanism still rem...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597485/ https://ncbi.nlm.nih.gov/pubmed/16768455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060107k |
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