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Liver-Specific Ablation of Integrin-Linked Kinase in Mice Results in Abnormal Histology, Enhanced Cell Proliferation, and Hepatomegaly

Hepatocyte differentiation and proliferation are greatly affected by extracellular matrix (ECM). Primary hepatocytes cultured without matrix dedifferentiate over time, but matrix overlay quickly restores differentiation. ECM also is critical in liver regeneration where ECM degradation and reconstitu...

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書誌詳細
主要な著者: Gkretsi, Vasiliki, Apte, Udayan, Mars, Wendy M., Bowen, William C., Luo, Jian-Hua, Yang, Yu, Yu, Yan P., Orr, Ann, St.-Arnaud, René, Dedhar, Shoukat, Kaestner, Klaus H., Wu, Chuanyue, Michalopoulos, George K.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597430/
https://ncbi.nlm.nih.gov/pubmed/18846549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22537
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