Liver-Specific Ablation of Integrin-Linked Kinase in Mice Results in Abnormal Histology, Enhanced Cell Proliferation, and Hepatomegaly

Hepatocyte differentiation and proliferation are greatly affected by extracellular matrix (ECM). Primary hepatocytes cultured without matrix dedifferentiate over time, but matrix overlay quickly restores differentiation. ECM also is critical in liver regeneration where ECM degradation and reconstitu...

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Detalhes bibliográficos
Main Authors: Gkretsi, Vasiliki, Apte, Udayan, Mars, Wendy M., Bowen, William C., Luo, Jian-Hua, Yang, Yu, Yu, Yan P., Orr, Ann, St.-Arnaud, René, Dedhar, Shoukat, Kaestner, Klaus H., Wu, Chuanyue, Michalopoulos, George K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597430/
https://ncbi.nlm.nih.gov/pubmed/18846549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22537
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