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Multiple steps determine the overall rate of the reduction of 5α-dihydrotestosterone catalyzed by human type 3 3α-hydroxysteroid dehydrogenase (AKR1C2): Implications for the Elimination of Androgens
Human type 3 3α-Hydroxysteroid dehydrogenase, or Aldo-Keto Reductase (AKR) 1C2, eliminates the androgen signal in human prostate by reducing 5α-dihydrotesterone (DHT, potent androgen) to form 3α-andostanediol (inactive androgen), thereby depriving the androgen receptor of its ligand. The k(cat) for...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597410/ https://ncbi.nlm.nih.gov/pubmed/17059222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060591r |
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