Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase

Non-ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) produce numerous secondary metabolites with various therapeutic/antibiotic properties1. Like fatty acid synthases (FAS), these enzymes are organized in modular assembly lines in which each module, made of conserved domains, inco...

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Main Authors: Frueh, Dominique P., Arthanari, Haribabu, Koglin, Alexander, Vosburg, David A., Bennett, Andrew E., Walsh, Christopher T., Wagner, Gerhard
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597408/
https://ncbi.nlm.nih.gov/pubmed/18704088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07162
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