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CD4(+) T lymphocytes mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate CD8(+) T-cell immune responses
There is evidence that the limited immunogenicity of plasmid DNA vaccines is the result, at least in part, of the rapid clearance of vaccine antigen expression by antigen-specific immune responses. However, the cell types responsible for the clearance of plasmid DNA vaccine antigens are not known. H...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597129/ https://ncbi.nlm.nih.gov/pubmed/18784371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-06-165803 |
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