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Modulation of Plasmid DNA Vaccine Antigen Clearance by Caspase 12 RNA Interference Potentiates Vaccination

The magnitude of the immune responses elicited by plasmid DNA vaccines might be limited, in part, by the duration of vaccine antigen expression in vivo. To explore strategies for improving plasmid DNA vaccine efficacy, we studied the apoptotic process in myocytes of mice vaccinated intramuscularly....

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Detalhes bibliográficos
Main Authors: Geiben-Lynn, Ralf, Frimpong-Boateng, Kwesi, Letvin, Norman L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122565/
https://ncbi.nlm.nih.gov/pubmed/21325489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00390-10
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