IL-17 Is a Critical Component of Vaccine-induced Protection against Lung Infection by LPS-heterologous Strains of Pseudomonas aeruginosa

In a murine model of acute fatal pneumonia, we previously showed that nasal immunization with a live-attenuated aroA deletant of P. aeruginosa strain PAO1 elicited LPS serogroup-specific protection, indicating that opsonic antibody to the LPS O antigen was the most important immune effector. Because...

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Main Authors: Priebe, Gregory P., Walsh, Rebecca L., Cederroth, Terra A., Kamei, Akinobu, Coutinho-Sledge, Yamara S., Goldberg, Joanna B., Pier, Gerald B.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597098/
https://ncbi.nlm.nih.gov/pubmed/18802100
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