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Intranasal immunization with heterologously expressed polysaccharide protects against multiple Pseudomonas aeruginosa infections

Surface-expressed bacterial polysaccharides are often immunodominant, protective antigens. However, these antigens are chemically and serologically highly heterogeneous, and conjugation to protein carriers is often necessary to enhance their immunogenicity. Here we show the efficacy of intranasal im...

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Main Authors: DiGiandomenico, Antonio, Rao, Jayasimha, Harcher, Katie, Zaidi, Tanweer S., Gardner, Jason, Neely, Alice N., Pier, Gerald B., Goldberg, Joanna B.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838651/
https://ncbi.nlm.nih.gov/pubmed/17360574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608657104
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