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Non-Covalent Modification of Chymotrypsin Surface using Amphiphilic Polymeric Scaffold – Implications in Modulating Protein Function
We report here on a new amphiphilic homopolymer that binds noncovalently to proteins. This polymer not only binds to the target protein chymotrypsin with sub-micromolar affinity, but also stabilizes the native structure of the protein. Since the polymer-protein binding process is based on electrosta...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2005
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596994/ https://ncbi.nlm.nih.gov/pubmed/16045357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja051947+ |
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