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Non-Covalent Modification of Chymotrypsin Surface using Amphiphilic Polymeric Scaffold – Implications in Modulating Protein Function

We report here on a new amphiphilic homopolymer that binds noncovalently to proteins. This polymer not only binds to the target protein chymotrypsin with sub-micromolar affinity, but also stabilizes the native structure of the protein. Since the polymer-protein binding process is based on electrosta...

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מידע ביבליוגרפי
Main Authors: Sandanaraj, Britto S., Vutukuri, Dharma Rao, Simard, Joseph M., Klaikherd, Akamol, Hong, Rui, Rotello, Vincent M., Thayumanavan, Sankaran
פורמט: Artigo
שפה:Inglês
יצא לאור: 2005
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596994/
https://ncbi.nlm.nih.gov/pubmed/16045357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja051947+
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