The Enhancing Effects of the Light Chain on Heavy Chain Secretion in Split Delivery of Factor VIII Gene

Coagulation factor VIII (FVIII) is secreted as a heterodimer consisting of a heavy chain (HC) and a light chain (LC), which can be expressed independently and reassociate with recovery of biological activity. Because of the size limitation of adeno-associated virus (AAV) vectors, a strategy for deli...

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Autors principals: Chen, Lingxia, Zhu, Fuxiang, Li, Juan, Lu, Hui, Jiang, Haiyan, Sarkar, Rita, Arruda, Valder R, Wang, Jinhui, Zhao, Jennifer, Pierce, Glenn F, Ding, Qiulan, Wang, Xuefeng, Wang, Hongli, Pipe, Steven W, Liu, Xiang-Qin, Xiao, Xiao, Camire, Rodney M, Xiao, Weidong
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596977/
https://ncbi.nlm.nih.gov/pubmed/17653101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.mt.6300268
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