Von Hippel-Lindau Tumor Suppressor Gene Loss in Renal Cell Carcinoma Promotes Oncogenic Epidermal Growth Factor Receptor Signaling via Akt-1 and MEK1

OBJECTIVES: Clear-cell renal cell carcinoma (RCC) is the most prevalent form of kidney cancer and is frequently associated with loss of von Hippel-Lindau (VHL) gene function, resulting in the aberrant transcriptional activation of genes that contribute to tumor growth and metastasis, including trans...

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Bibliographische Detailangaben
Hauptverfasser: Lee, S. Justin, Lattouf, Jean-Baptiste, Xanthopoulos, Julie, Linehan, W. Marston, Bottaro, Donald P., Vasselli, James R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596938/
https://ncbi.nlm.nih.gov/pubmed/18243508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2008.01.010
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