Optimized Clostridia-Directed Enzyme Prodrug Therapy Improves the Antitumor Activity of the Novel DNA-Cross-Linking Agent PR-104

We have demonstrated previously that spores of the non-pathogenic Clostridial strain C. sporogenes genetically engineered to express the E. coli-derived cytosine deaminase (CD) gene are effective in converting systemically injected nontoxic 5-fluorocytosine (5-FC) into the toxic anticancer drug 5-fl...

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Bibliographic Details
Main Authors: Liu, Shie-Chau, Ahn, G-One, Kioi, Mitomu, Dorie, Mary-Jo, Patterson, Adam V., Brown, J. Martin
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596930/
https://ncbi.nlm.nih.gov/pubmed/18829557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1698
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