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Optimized Clostridia-Directed Enzyme Prodrug Therapy Improves the Antitumor Activity of the Novel DNA-Cross-Linking Agent PR-104
We have demonstrated previously that spores of the non-pathogenic Clostridial strain C. sporogenes genetically engineered to express the E. coli-derived cytosine deaminase (CD) gene are effective in converting systemically injected nontoxic 5-fluorocytosine (5-FC) into the toxic anticancer drug 5-fl...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596930/ https://ncbi.nlm.nih.gov/pubmed/18829557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1698 |
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