SSADH deficiency leads to elevated extracellular GABA levels and increased GABAergic neurotransmission in the mouse cerebral cortex

SUMMARY: Succinic semialdehyde dehydrogenase (SSADH) deficiency is an inherited disorder in which patients display neurodevelopmental retardation, ataxia, and epileptic seizures. The recently engineered SSADH knock-out (KO) mouse models the severe form of the human disorder. The SSADH enzyme partici...

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Bibliographic Details
Main Authors: Drasbek, K. R., Vardya, I., Delenclos, M., Gibson, K. M., Jensen, K.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596865/
https://ncbi.nlm.nih.gov/pubmed/18696252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10545-008-0941-7
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