Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

Double negative (DN) T cells are expanded in patients with systemic lupus erythematosus (SLE) and stimulate autoantibody production as efficiently as CD4(+) T cells. Here we demonstrate that DN T cells from patients with SLE produce significant amounts of IL-17 and IFN-γ, and expand when stimulated...

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Main Authors: Crispín, José C., Oukka, Mohammed, Bayliss, George, Cohen, Robert A., Van Beek, Christine A., Stillman, Isaac E., Kyttaris, Vasileios C., Juang, Yuang-Taung, Tsokos, George C.
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596652/
https://ncbi.nlm.nih.gov/pubmed/19050297
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