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Systemic Targeting of CpG-ODN to the tumor microenvironment with anti-neu-CpG hybrid-molecule and T-reg depletion induces memory responses in BALB-neuT tolerant mice
We have demonstrated that neu transgenic mice are immuno-tolerant and that immunizations with DCs pulsed with neu-derived antigens were not able to control tumor growth in these animals. We tested whether by modulating the tumor microenvironment with TLR-ligands it could be possible to induce the ac...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596586/ https://ncbi.nlm.nih.gov/pubmed/18794141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1635 |
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