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Structure and Hemimethylated CpG Binding of the SRA Domain from Human UHRF1
Human UHRF1 (ubiquitin-like PHD and RING finger 1) functions to maintain CpG DNA methylation patterns through DNA replication by co-localizing with the DNA methyltransferase DNMT1 at chromatin in mammals. Recent studies show that UHRF1 binds selectively to hemimethylated CpG via its conserved SRA (S...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596396/ https://ncbi.nlm.nih.gov/pubmed/18945682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C800169200 |
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