Evolution of Enzymatic Activity in the Tautomerase Superfamily: Mechanistic and Structural Consequences of the L8R Mutation in 4-Oxalocrotonate Tautomerase,

4-Oxalocrotonate tautomerase (4-OT) and trans-3-chloroacrylic acid dehalogenase (CaaD) are members of the tautomerase superfamily, a group of structurally homologous proteins that share a β-α-β fold and a catalytic amino-terminal proline. 4-OT, from Pseudomonas putida mt-2, catalyzes the conversion...

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Hauptverfasser: Poelarends, Gerrit J., Almrud, Jeffrey J., Serrano, Hector, Darty, Joseph E., Johnson, William H., Hackert, Marvin L., Whitman, Christian P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596063/
https://ncbi.nlm.nih.gov/pubmed/16784221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0600603
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