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Inhibition of Hb S Polymerization In Vitro by a Novel 15-mer EF Helix β73 His-Containing Peptide
Our mutational studies on HbS showed that the HbS β73His variant (β6Val and β73His) promoted polymerization, while HbS β73Leu (β6Val and β73Leu) inhibited polymerization. Based on these results, we speculated that EF-helix peptides containing β73His interact with β4Thr in HbS and compete with HbS, r...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2593912/ https://ncbi.nlm.nih.gov/pubmed/16819835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0604734 |
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