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Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: exploring possible relationship to the longevity phenotype

Mice born with the deletion of the gene for pregnancy-associated plasma protein-A (PAPP-A), a model of reduced local IGF activity, live ~30% longer than their wild-type (WT) littermates. In this study, we investigated metabolic consequences of PAPP-A gene deletion and possible relationship to lifesp...

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Détails bibliographiques
Auteurs principaux: Conover, Cheryl A, Mason, Megan A, Levine, James A, Novak, Colleen M
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593875/
https://ncbi.nlm.nih.gov/pubmed/18566100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JOE-08-0179
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