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Efficient Synthesis of Suitably Protected β-Difluoroalanine and γ-Difluorothreonine from L-Ascorbic Acid
Fluorinated amino acids are useful building blocks for the preparation of biologically active peptides and peptidomimetics with increased metabolic stability. We report here the synthesis of two fluorinated amino acids, β-difluoroalanine and γ-difluorothreonine as analogs of Ser and Thr, respectivel...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2593874/ https://ncbi.nlm.nih.gov/pubmed/17192080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol062401a |
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