Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

T cell activation potently stimulates cellular metabolism to support the elevated energetic and biosynthetic demands of growth, proliferation, and effector function. We show that glucose uptake is limiting in T cell activation and that CD28 costimulation is required to allow maximal glucose uptake f...

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Bibliographic Details
Main Authors: Jacobs, Sarah R., Herman, Catherine E., MacIver, Nancie J., Wofford, Jessica A., Wieman, Heather L., Hammen, Jeremy J., Rathmell, Jeffrey C.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593791/
https://ncbi.nlm.nih.gov/pubmed/18354169
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