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Closing the circadian negative feedback loop: FRQ-dependent clearance of WC-1 from the nucleus
In Neurospora crassa, a transcription factor, WCC, activates the transcription of frq. FRQ forms homodimers as well as complexes with an RNA helicase, FRH, and the WCC, and translocates into the nucleus to inactivate the WCC, closing the time-delayed negative feedback loop. The detailed mechanism fo...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2593610/ https://ncbi.nlm.nih.gov/pubmed/18997062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1706908 |
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