Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances α(1D)-adrenergic receptor constriction

G protein-coupled receptor kinase 2 (GRK2) is a serine/theorinine kinase that phosphorylates and desensitizes agonist-bound G protein-coupled receptors. GRK2 is increased in expression and activity in lymphocytes and vascular smooth muscle (VSM) in human hypertension and animal models of the disease...

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Main Authors: Cohn, Heather Irina, Harris, David M., Pesant, Stephanie, Pfeiffer, Michael, Zhou, Rui-Hai, Koch, Walter J., Dorn, Gerald W., Eckhart, Andrea D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593515/
https://ncbi.nlm.nih.gov/pubmed/18723764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00564.2008
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