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A Genome-Wide Screen for β-Catenin Binding Sites Identifies a Downstream Enhancer Element That Controls c-Myc Gene Expression

Mutations in components of the Wnt signaling pathway initiate colorectal carcinogenesis by deregulating the β-catenin transcriptional coactivator. β-Catenin activation of one target in particular, the c-Myc proto-oncogene, is required for colon cancer pathogenesis. β-Catenin is known to regulate c-M...

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Detalhes bibliográficos
Main Authors: Yochum, Gregory S., Cleland, Ryan, Goodman, Richard H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593444/
https://ncbi.nlm.nih.gov/pubmed/18852287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00744-08
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