Epigenetic Silencing of Human Immunodeficiency Virus (HIV) Transcription by Formation of Restrictive Chromatin Structures at the Viral Long Terminal Repeat Drives the Progressive Entry of HIV into Latency

The molecular mechanisms utilized by human immunodeficiency virus (HIV) to enter latency are poorly understood. Following the infection of Jurkat T cells with lentiviral vectors that express Tat in cis, gene expression is progressively silenced. Silencing is greatly enhanced when the lentiviral vect...

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Detalhes bibliográficos
Main Authors: Pearson, Richard, Kim, Young Kyeung, Hokello, Joseph, Lassen, Kara, Friedman, Julia, Tyagi, Mudit, Karn, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593349/
https://ncbi.nlm.nih.gov/pubmed/18829756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01383-08
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