Topology and Membrane Anchoring of the Coronavirus Replication Complex: Not All Hydrophobic Domains of nsp3 and nsp6 Are Membrane Spanning

Coronaviruses express two very large replicase polyproteins, the 16 autoproteolytic cleavage products of which collectively form the membrane-anchored replication complexes. How these structures are assembled is still largely unknown, but it is likely that the membrane-spanning members of these nons...

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Main Authors: Oostra, Monique, Hagemeijer, Marne C., van Gent, Michiel, Bekker, Cornelis P. J., te Lintelo, Eddie G., Rottier, Peter J. M., de Haan, Cornelis A. M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Genome Replication and Regulation of Viral Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593338/
https://ncbi.nlm.nih.gov/pubmed/18842706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01219-08
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