Neuroadapted Yellow Fever Virus Strain 17D: a Charged Locus in Domain III of the E Protein Governs Heparin Binding Activity and Neuroinvasiveness in the SCID Mouse Model

A molecular clone of yellow fever virus (YFV) strain 17D was used to identify critical determinants of mouse neuroinvasiveness previously localized to domain III of the neuroadapted SPYF-MN virus envelope protein. Three candidate virulence substitutions (305F→V, 326K→E, and 380R→T) were individually...

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Bibliographic Details
Main Authors: Nickells, Janice, Cannella, Maria, Droll, Deborah A., Liang, Yan, Wold, William S. M., Chambers, Thomas J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593324/
https://ncbi.nlm.nih.gov/pubmed/18842715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00458-08
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