Identification of a Residue in Hepatitis C Virus E2 Glycoprotein That Determines Scavenger Receptor BI and CD81 Receptor Dependency and Sensitivity to Neutralizing Antibodies

Hepatitis C virus (HCV) infection is dependent on at least three coreceptors: CD81, scavenger receptor BI (SR-BI), and claudin-1. The mechanism of how these molecules coordinate HCV entry is unknown. In this study we demonstrate that a cell culture-adapted JFH-1 mutant, with an amino acid change in...

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Detaylı Bibliyografya
Asıl Yazarlar: Grove, Joe, Nielsen, Søren, Zhong, Jin, Bassendine, Margaret F., Drummer, Heidi E., Balfe, Peter, McKeating, Jane A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2008
Konular:
Virus-Cell Interactions
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593310/
https://ncbi.nlm.nih.gov/pubmed/18829747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01569-08
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