Efficacy of the Combination of Tachyplesin III and Clarithromycin in Rat Models of Escherichia coli Sepsis

We investigated the efficacy of tachyplesin III and clarithromycin in two experimental rat models of severe gram-negative bacterial infections. Adult male Wistar rats were given either (i) an intraperitoneal injection of 1 mg/kg Escherichia coli 0111:B4 lipopolysaccharide or (ii) 2 × 10(10) CFU of E...

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Autors principals: Cirioni, Oscar, Ghiselli, Roberto, Silvestri, Carmela, Kamysz, Wojciech, Orlando, Fiorenza, Riva, Alessandra, Kamysz, Elzbieta, Castelletti, Sefora, Rocchi, Marco, Saba, Vittorio, Scalise, Giorgio, Giacometti, Andrea
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592857/
https://ncbi.nlm.nih.gov/pubmed/18779356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00086-08
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