Efficacy of the Combination of Tachyplesin III and Clarithromycin in Rat Models of Escherichia coli Sepsis

We investigated the efficacy of tachyplesin III and clarithromycin in two experimental rat models of severe gram-negative bacterial infections. Adult male Wistar rats were given either (i) an intraperitoneal injection of 1 mg/kg Escherichia coli 0111:B4 lipopolysaccharide or (ii) 2 × 10(10) CFU of E...

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Hauptverfasser: Cirioni, Oscar, Ghiselli, Roberto, Silvestri, Carmela, Kamysz, Wojciech, Orlando, Fiorenza, Riva, Alessandra, Kamysz, Elzbieta, Castelletti, Sefora, Rocchi, Marco, Saba, Vittorio, Scalise, Giorgio, Giacometti, Andrea
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592857/
https://ncbi.nlm.nih.gov/pubmed/18779356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00086-08
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