Impact of Self-Assembly Properties on Antibacterial Activity of Short Acyl-Lysine Oligomers

We investigated both the structural and functional consequences of modifying the hydrophobic, lipopeptide-mimetic oligo-acyl-lysine (OAK) N(α)-hexadecanoyl-l-lysyl-l-lysyl-aminododecanoyl-l-lysyl-amide (c(16)KKc(12)K) to its unsaturated analog hexadecenoyl-KKc(12)K [c(16(ω7))KKc(12)K]. Despite simil...

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Bibliografiske detaljer
Main Authors: Sarig, Hadar, Rotem, Shahar, Ziserman, Lior, Danino, Dganit, Mor, Amram
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592853/
https://ncbi.nlm.nih.gov/pubmed/18838600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00656-08
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