A polymorphism in the human serotonin 5-HT(2A )receptor gene may protect against systemic sclerosis by reducing platelet aggregation

INTRODUCTION: Platelet aggregation may contribute to the pathogenesis of systemic sclerosis: following activation, platelets release significant amounts of serotonin – which promotes vasoconstriction and fibrosis, and further enhances aggregation. The C+1354T polymorphism in the exonic region of the...

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Autors principals: Beretta, Lorenzo, Cossu, Marta, Marchini, Maurizio, Cappiello, Francesca, Artoni, Andrea, Motta, Giovanna, Scorza, Raffaella
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2008
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592780/
https://ncbi.nlm.nih.gov/pubmed/18761744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2495
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