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A polymorphism in the human serotonin 5-HT(2A )receptor gene may protect against systemic sclerosis by reducing platelet aggregation
INTRODUCTION: Platelet aggregation may contribute to the pathogenesis of systemic sclerosis: following activation, platelets release significant amounts of serotonin – which promotes vasoconstriction and fibrosis, and further enhances aggregation. The C+1354T polymorphism in the exonic region of the...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2592780/ https://ncbi.nlm.nih.gov/pubmed/18761744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2495 |
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