Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays

We present a strategy for detection of loss-of-heterozygosity and allelic imbalance in cancer cells from whole genome single nucleotide polymorphism genotyping data. Using a dilution series of a tumor cell line mixed with its paired normal cell line and data generated on Affymetrix and Illumina plat...

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Bibliographic Details
Main Authors: Staaf, Johan, Lindgren, David, Vallon-Christersson, Johan, Isaksson, Anders, Göransson, Hanna, Juliusson, Gunnar, Rosenquist, Richard, Höglund, Mattias, Borg, Åke, Ringnér, Markus
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
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Method
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592714/
https://ncbi.nlm.nih.gov/pubmed/18796136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2008-9-9-r136
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