Phosphorylation by Cdk1 Increases the Binding of Eg5 to Microtubules In Vitro and in Xenopus Egg Extract Spindles

BACKGROUND: Motor proteins from the kinesin-5 subfamily play an essential role in spindle assembly during cell division of most organisms. These motors crosslink and slide microtubules in the spindle. Kinesin-5 motors are phosphorylated at a conserved site by Cyclin-dependent kinase 1 (Cdk1) during...

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Main Authors: Cahu, Julie, Olichon, Aurelien, Hentrich, Christian, Schek, Henry, Drinjakovic, Jovana, Zhang, Cunjie, Doherty-Kirby, Amanda, Lajoie, Gilles, Surrey, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592692/
https://ncbi.nlm.nih.gov/pubmed/19079595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003936
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