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Acute Myeloid Leukemia-Targeted Toxin Activates Both Apoptotic and Necroptotic Death Mechanisms

BACKGROUND: Acute myelogenous leukemia (AML) is the second most common leukemia with approximately 13,410 new cases and 8,990 deaths annually in the United States. A novel fusion toxin treatment, diphtheria toxin GM-CSF (DT-GMCSF) has been shown to selectively eliminate leukemic repopulating cells t...

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書誌詳細
主要な著者: Horita, Henrick, Frankel, Arthur E., Thorburn, Andrew
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592546/
https://ncbi.nlm.nih.gov/pubmed/19079542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003909
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